The Romberg Lab investigates the regulatory mechanisms that enable our immune systems to vigorously attack infectious pathogens but not our own bodies. Particular topics of interest include:
- The role of T regulatory cells in B cell tolerance
- T follicular helper cell dysfunction in Common Variable Immune Deficiency-related autoimmune disease
- The role of novel genes and pathways in immunity
We are particularly interested in studying the immune system of patients with primary immune deficiencies (PID) who are susceptible to both life-threatening infections and to the development of autoimmune diseases. Greater insights into the pathology of these rare diseases will enable the rationale development of targeted therapies for PIDs and for more common diseases that have an immunologic basis.